Precision Oncology in Practice: Relevance of DPYD genotyping and implementation of rapid methylation, lung and AML panels for faster results

Wednesday, November 12, 2025 | 1:00 – 1:50 PM EST
Room #159, Level 1

Join Dr. Jai Patel, Associate VP of Translational Research and Director of Cancer Pharmacology & Pharmacogenomics at Atrium Health Levine Cancer, and Dr. Laila Mnayer, Director of Molecular Pathology & Cytogenetics at Hartford Hospital, as they share how targeted genomic approaches are advancing oncology research.

This session will explore the relevance of DPYD gene analysis for AMP-recommended variants and how targeted panels for NSCLC and AML, together with methylation analysis for MGMT and MLH1, are enabling faster, more streamlined research workflows. Attendees will gain insights into implementing rapid, scalable methods that deliver high-quality data within 48 – 72 hours using the MassARRAY® System.

Learning Objectives

  • Understand the importance of DPYD variant detection in oncology research.
  • Explore the use of targeted panels for NSCLC and AML research applications.
  • Learn how methylation analysis of MGMT and MLH1 contributes to comprehensive molecular profiling.
  • Discover how the MassARRAY® System enables rapid, scalable workflows for oncology research.

An AMP Annual Meeting badge or Corporate Workshop Day badge is required to attend this workshop.

PRESENTED BY:

Dr. Jai Patel - AMP 2025

Jai Patel, PharmD

Associate Vice President Translational Research; Director of Cancer Pharmacology & Pharmacogenomics; Associate Professor, Cancer Biology 

Dr. Jai Patel is the Associate Vice President of Translational Research and Director of Cancer Pharmacology & Pharmacogenomics at Atrium Health Levine Cancer and Associate Director for Shared Resources Management at Atrium Health Wake Forest Baptist Comprehensive Cancer CenterHe is also Associate Professor in the Department of Cancer Biology at the Wake Forest University School of Medicine.

Dr. Patel received his Doctorate in Pharmacy from the University of North Carolina Eshelman School of Pharmacy and completed an oncology pharmacogenomics postdoctoral fellowship at the UNC Center for Pharmacogenomics and Individualized Therapy. Dr. Patel leads translational and clinical pharmacology research at the cancer center, with an emphasis on pharmacogenomics research and implementation, and oversees pharmacogenomics integration across the health enterprise. Dr. Patel has published over 170 articles, editorials, book chapters and abstracts on the topics of pharmacogenomics, pharmacology, and pharmaceutical sciences.  

Laila Mnayer

Laila Mnayer, MS, PhD, ABMGG, FACMG 

Division Director, Molecular Pathology and Cytogenetics  

Dr. Mnayer’s experience in clinical genetics and cytogenetics spans over 25 years.  She trained initially in cytogenetics/oncology at The Royal Free Hospital in England as the recipient of a United Nations fellowship.  She then studied clinical cytogenetics at Georgetown University Hospital as a WHO fellow.  Dr. Mnayer subsequently obtained her PhD in Biochemistry and Molecular Genetics at the University in Miami, and completed a 3-year postdoctoral fellowship in clinical molecular genetics at the McDonald’s Foundation for Medical Genetics-Miller School of Medicine at the University of Miami.  She also completed a 2-year postdoctoral fellowship in clinical cytogenetics at Tufts New England Medical Center, and has received dual certification by the American College of Genetics and Genomics in Clinical Molecular Genetics and Clinical Cytogenetics.  Dr. Mnayer has directed the Molecular Pathology and Cytogenetics Laboratories at Hartford Hospital since 2006, and has introduced myriad clinical assays and testing platforms during that time.  She established clinical cytogenetics services in 2008, and subsequently introduced cytogenomic microarrays for the diagnosis of congenital abnormalities and tumor profiling.  In 2017, Dr. Mnayer launched next-generation sequencing (NGS) for solid tumors and leukemias/lymphomas.  More recently, she has expanded the NGS panels to incorporate newer molecular substrates for targeted therapies.  Furthermore, very recently she introduced multiple Rapid Molecular Panels that run on the MassARRAY for the timely identification of biomarkers essential for targeted therapy in lung cancer, acute myeloid leukemia and others.  Dr. Mnayer’s highly skilled team includes technologists, and individuals with expertise in bioinformatics, information technology, and administration.  Dr. Mnayer also works closely with her colleagues in the Department of Pathology & Laboratory Medicine, as well as the oncologists who rely upon the work performed in her laboratory, to ensure that the Molecular Pathology & Cytogenetics Laboratories at Hartford Hospital remain at the cutting edge of technology.  She also participates in several tumor boards and disease management teams including intercity heme-oncology, breast, thoracic, and gynecology. 

Dr. Mnayer is a fellow of the American College of Medical Genetics and Genomics (ACMGG), a member of the Association of Molecular Pathology (AMP), a member of the International Association for the Study of Lung Cancer (IASLC), Children’s Oncology Group (COG), American Cytogenetics Conference (ACC), and a member of the Atlas of Genetics and Cytogenetics in Oncology and Haematology.   

Dr. Mnayer serves on the advisory boards of several biotech and pharmaceutical companies including Bristol Myers Squibb (BMS), Eli Lilly, Novartis, Personal Genome Diagnostics (PGDx), and Asuragen.  

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